There is no clear-cut answer to this question. Although Botswana’s malaria-risk is lower than some other African nations, there is still a certain risk associated with travel through the beautiful Botswana bush.
It’s therefore advised that you practice precautions before you travel to Botswana. Anti-malaria medication is a must - and you should consult your doctor in this regard. Further precautions such as long-sleeved shirts and jeans in the evenings will reduce your chances of mosquito bites. Pack some mosquito repellent, cream or spray, for applying to your hands, face and neck. This will also help keep the mosquitoes at bay.
The colder dry winter months have less mosquito activity. May through to October is best. Additionally, areas with less people have less risk of transmission, even if there is water – Kalahari, Okavango and Moremi concessions and the Makgadikgadi Pans are low risk areas.